![]() ![]() 3D printing has been widely investigated as a promising strategy for fabrication of bone tissue engineering scaffolds. The purpose of a scaffold is to create a 3D platform for cell and tissue growth. To provide tissue repair and regeneration, a scaffold is utilized as a replacement for missing bone at the site of the defect, with or without bone-specific growth factors and (or) cells. Natural bone is a composite material consisting of mineralized extracellular matrix (ECM) and cells which is complex and hierarchically structured. Graphical abstractīone is a unique tissue that can repair damage after it occurs. The coating process was found to be a fast, economical and effective way to improve the biomineralization and promote the differentiation of the stem cells toward osteoblasts, in comparison with the neat PLA and the PLA/MMT nanocomposite scaffold. Finally, the in vitro biocompatibility and osteogenic potential were evaluated using bone marrow-derived stem cells. Moreover, in the case of PLA/MMT/SrBG/nHA 3D printed scaffolds, the elastic modulus increased by ~ 80% and the hardness increased from 156.9 ± 6.4 to 293.6 ± 11.3 MPa in comparison with PLA. The hydrophilicity of PLA nanocomposite scaffolds increased after the SrBG coating and increased even more with the SrBG/nHA coating. The effect of the coatings on the morphology, chemical structure, wettability and nanomechanical properties of the scaffolds was examined. To improve their suitability for bone tissue engineering applications, the PLA nanocomposite scaffolds were coated with (i) ordered mesoporous Strontium bioglass (SrBG) and (ii) SrBG and nanohydroxyapatite (nHA) using a simple dip coating procedure. In this work, the effect of two different types of bioactive coatings on the properties of 3D printed poly(lactic acid)/montmorillonite (PLA/MMT) nanocomposite scaffolds was examined. ![]()
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